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EIPA hydrochloride

Names

[ CAS No. ]:
1345839-28-2

[ Name ]:
EIPA hydrochloride

Biological Activity

[Description]:

EIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM[1]. EIPA also inhibits Na+/H+-exchanger (NHE)[2] and macropinocytosis[3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[Target]

IC50: 10.5 μM (TRPP3 channel)[1] NHE[2] Macropinocytosis[3]


[References]

[1]. Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85.

[2]. Shi H, et al. Na+/H+ Exchanger Regulates Amino Acid-Mediated Autophagy in Intestinal Epithelial Cells. Cell Physiol Biochem. 2017;42(6):2418-2429.

[3]. Zhu BY, et al. A new HDAC inhibitor cinnamoylphenazine shows antitumor activity in association with intensive macropinocytosis.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H19Cl2N7O

[ Molecular Weight ]:
336.22

[ Storage condition ]:
2-8℃

Related Compounds