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Deferiprone-d3

Names

[ CAS No. ]:
1346601-82-8

[ Name ]:
Deferiprone-d3

[Synonym ]:
3-Hydroxy-2-methyl-1-(2H3)methyl-4(1H)-pyridinone
4(1H)-Pyridinone, 3-hydroxy-2-methyl-1-(methyl-d3)-
DEFERIPRONE-D3

Biological Activity

[Description]:

Deferiprone-d3 is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Anti-infection >> HCV
Signaling Pathways >> Apoptosis >> Ferroptosis

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
232.7±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H6D3NO2

[ Molecular Weight ]:
142.170

[ Flash Point ]:
94.5±27.3 °C

[ Exact Mass ]:
142.082153

[ LogP ]:
-0.22

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.565

Related Compounds