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Azoxystrobin-d4

Names

[ CAS No. ]:
1346606-39-0

[ Name ]:
Azoxystrobin-d4

[Synonym ]:
Benzeneacetic acid, 2-[[6-[(6-cyanophenyl-2,3,4,5-d)oxy]-4-pyrimidinyl]oxy]-α-(methoxymethylene)-, methyl ester, (αE)-
Methyl (2E)-2-{2-[(6-{[2-cyano(H)phenyl]oxy}-4-pyrimidinyl)oxy]phenyl}-3-methoxyacrylate

Biological Activity

[Description]:

Azoxystrobin-d4 is deuterium labeled Azoxystrobin. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Enock Mpofu, et al. Azoxystrobin amine: A novel azoxystrobin degradation product from Bacillus licheniformis strain TAB7. Chemosphere. 2021 Jun;273:129663.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
581.3±50.0 °C at 760 mmHg

[ Melting Point ]:
105-107°C

[ Molecular Formula ]:
C22H13D4N3O5

[ Molecular Weight ]:
407.41

[ Flash Point ]:
305.3±30.1 °C

[ Exact Mass ]:
407.141937

[ LogP ]:
5.13

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
2-8°C

Related Compounds