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Linderane

Names

[ CAS No. ]:
13476-25-0

[ Name ]:
Linderane

[Synonym ]:
(1S,4E,12S,13S)-5,10-Dimethyl-8,14,16-trioxatetracyclo[10.2.2.0.0]hexadeca-4,7(11),9-trien-15-one
2H-10,1a-(Epoxymethano)oxireno[4,5]cyclodeca[1,2-b]furan-12-one, 3,6,10,10a-tetrahydro-5,9-dimethyl-, (1aS,4E,10S,10aS)-

Biological Activity

[Description]:

Linderane, isolated from the root of Lindera strychnifolia, is an irreversible inhibitor cytochrome P450 2C9 (CYP2C9). Linderane has the potential to relieve pain and cramp[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Inflammation/Immunology

[References]

[1]. Wang H, et al. Mechanism-based inactivation of CYP2C9 by linderane. Xenobiotica. 2015;45(12):1037-46.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
434.5±45.0 °C at 760 mmHg

[ Melting Point ]:
190-191ºC

[ Molecular Formula ]:
C15H16O4

[ Molecular Weight ]:
260.285

[ Flash Point ]:
216.6±28.7 °C

[ Exact Mass ]:
260.104858

[ PSA ]:
51.97000

[ LogP ]:
2.49

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.589

[ Storage condition ]:
2~8°C

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

Related Compounds