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m-PEG5-CH2CH2COOH

Names

[ CAS No. ]:
1347750-72-4

[ Name ]:
m-PEG5-CH2CH2COOH

[Synonym ]:
2,5,8,11,14,17-Hexaoxaicosan-20-oic acid
MFCD20926383
2,5,8,11,14,17-Hexaoxaeicosan-20-oic acid

Biological Activity

[Description]:

m-PEG5-CH2CH2COOH is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Parva Yogeshchandra Purohit, et al. Prodrugs of fulvestrant. WO2019224790A2.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
431.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H28O8

[ Molecular Weight ]:
324.367

[ Flash Point ]:
148.5±22.2 °C

[ Exact Mass ]:
324.178406

[ LogP ]:
-2.07

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.452

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds