<Suppliers Price>

Boc-N-amido-PEG3-acid

Names

[ CAS No. ]:
1347750-75-7

[ Name ]:
Boc-N-amido-PEG3-acid

[Synonym ]:
2,2-Dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azaheptadecan-17-oic acid
3,8,11,14-Tetraoxa-5-azaheptadecan-17-oic acid, 2,2-dimethyl-4-oxo-
Boc-9-AMino-4,7-Dioxanonanoic acid
t-Boc-N-amido-PEG3-acid

Biological Activity

[Description]:

Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
471.1±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H27NO7

[ Molecular Weight ]:
321.367

[ Flash Point ]:
238.7±27.3 °C

[ Exact Mass ]:
321.178741

[ LogP ]:
0.22

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.465

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds