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Thiol-PEG6-acid

Names

[ CAS No. ]:
1347750-77-9

[ Name ]:
Thiol-PEG6-acid

[Synonym ]:
3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-mercapto-
MFCD26127814
1-Sulfanyl-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid

Biological Activity

[Description]:

Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
495.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H30O8S

[ Molecular Weight ]:
370.459

[ Flash Point ]:
253.2±28.7 °C

[ Exact Mass ]:
370.166138

[ LogP ]:
-1.37

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.478

Related Compounds