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UNC-1062

Names

[ CAS No. ]:
1350549-36-8

[ Name ]:
UNC-1062

[Synonym ]:
UNC-1062
T7755XP5Y6
Cyclohexanol, 4-[6-(butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, trans-
trans-4-{6-(Butylamino)-3-[4-(4-morpholinylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}cyclohexanol

Biological Activity

[Description]:

UNC-1062 is a potent and selective Mer kinase inhibitor with IC50 of 1.1 nM, Ki of 0.33 nM; shows improved selectivity and activity against Mer relative to other TAM family RTKs (78-fold selectivity over Axl and 36-fold over Tyro3); inhibits Mer auto-phosphorylation in human pre-B leukemia 697 cells with IC50 of 6.4 nM, also inhibits colony formation in soft agar in tumor cells.

[References]

References 1. Schlegel J, et al. J Clin Invest. 2013 May;123(5):2257-67. 2. Liu J, et al. Eur J Med Chem. 2013 Jul;65:83-93. 3. von Mässenhausen A, et al. Oncotarget. 2016 May 31;7(22):32678-94. View Related Products by Target TAM Receptor (Tyro3-Axl-Mer)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
744.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H34N6O4S

[ Molecular Weight ]:
514.640

[ Flash Point ]:
403.8±35.7 °C

[ Exact Mass ]:
514.236206

[ LogP ]:
2.66

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.697

Related Compounds