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Febuxostat acyl glucuronide

Names

[ CAS No. ]:
1351692-92-6

[ Name ]:
Febuxostat acyl glucuronide

[Synonym ]:
Febuxostat Acyl-|A-D-glucuronide
2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate |A-D-Glucopyranuronic Acid
2-(3-Cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylate |A-D-Glucopyranuronic Acid

Biological Activity

[Description]:

Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[References]

[1]. Bishoy Kamel, et al. Clinical Pharmacokinetics and Pharmacodynamics of Febuxostat. Clin Pharmacokinet. 2017 May;56(5):459-475.  

[2]. Kamel B, et al. Clinical Pharmacokinetics and Pharmacodynamics of Febuxostat. Clin Pharmacokinet. 2017 May;56(5):459-475.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H24N2O9S

[ Molecular Weight ]:
492.50

[ Exact Mass ]:
492.12000

[ PSA ]:
207.67000

[ LogP ]:
1.07398

Related Compounds