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poststatin

Names

[ CAS No. ]:
135219-43-1

[ Name ]:
poststatin

[Synonym ]:
L-Valine, N-[(3S)-3-amino-1,2-dioxopentyl]-D-leucyl-N-[(2S,6S)-2,6-diamino-3,7-dimethyl-1,5-dioxooctyl]-
N-[(3S)-3-Amino-2-oxopentanoyl]-D-leucyl-N-[(2S,6S)-2,6-diamino-3,7-dimethyl-5-oxooctanoyl]-L-valine

Biological Activity

[Description]:

Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. T Aoyagi, et al. Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1991 Sep;44(9):949-55.  

[2]. M Majima, et al. Poststatin, a novel inhibitor of bradykinin-degrading enzymes in rat urine. Eur J Pharmacol. 1993 Mar 2;232(2-3):181-90.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C26H47N5O7

[ Molecular Weight ]:
541.681

[ Exact Mass ]:
541.347534

[ LogP ]:
1.91

[ Index of Refraction ]:
1.517

Related Compounds