CR-1-31-B

CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF)

CR-1-31-B (100 nM; 24 hours) inhibits MUC1-C translation in MCF-10A cells[1]. CR-1-31-B (10 and 100 nM) decreases MUC1-C abundance in MDA-MB-468 breast cancer cells[1]. Western Blot Analysis[1] Cell Line: MCF-10A cells (EGF/HRG stimulated) Concentration: 100 nM Incubation Time: 24 hours Result: EGF-stimulated MCF-10A cells was associated with a dose-dependent decrease in MUC1-C abundance; Blocked HRG-induced increases in MUC1-C abundance.

[1]. Jin C, Rajabi H, Rodrigo CM, Porco JA Jr, Kufe D. Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein. Oncogene. 2013;32(17):2179-2188.