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9-(3-fluoro-2-phosphonylmethoxypropyl)adenine

Names

[ CAS No. ]:
135295-27-1

[ Name ]:
9-(3-fluoro-2-phosphonylmethoxypropyl)adenine

[Synonym ]:
9-(RS)-(3-fluoro-2-phosphonomethoxypropyl)adenine
RS-FPMPA
9-(3-Fluoro-2-phosphonylmethoxypropyl)-adenine
[2-(6-Amino-purin-9-yl)-1-fluoromethyl-ethoxymethyl]-phosphonic acid

Biological Activity

[Description]:

(2RS)-FPMPA can be used for synthesis of antiretroviral agents against HIV-1 and HIV-2[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[References]

[1]. Balzarini J, et al. 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4961-5.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H13FN5O4P

[ Molecular Weight ]:
305.20300

[ Exact Mass ]:
305.06900

[ PSA ]:
146.19000

[ LogP ]:
0.47960

Related Compounds