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RP-54745

Names

[ CAS No. ]:
135330-08-4

[ Name ]:
RP-54745

[Synonym ]:
3H-1,2-Dithiol-3-one,4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)
4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one
RP-54745

Biological Activity

[Description]:

RP 54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Research Areas >> Inflammation/Immunology

[In Vitro]

RP 54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1].

[In Vivo]

RP 54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP 54745[2].

[References]

[1]. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26.

[2]. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35.


[Related Small Molecules]

DMXAA (Vadimezan) | apilimod | SC144 | APY0201 | Vidofludimus | Diacerein | AX-024 hydrochloride | Ginsenoside Rh1 | BAY 2402234 | Neochlorogenic acid | Y-320 | GIBH-130 | Ginsenoside Rc | Mulberroside A | Suplatast Tosilate

Chemical & Physical Properties

[ Density]:
1.46g/cm3

[ Boiling Point ]:
411.4ºC at 760 mmHg

[ Molecular Formula ]:
C13H12ClNOS2

[ Molecular Weight ]:
297.82300

[ Flash Point ]:
202.6ºC

[ Exact Mass ]:
297.00500

[ PSA ]:
76.79000

[ LogP ]:
4.01190

[ Vapour Pressure ]:
5.59E-07mmHg at 25°C

[ Index of Refraction ]:
1.707

[ Storage condition ]:
2-8℃

Related Compounds