AQ-101

Names

[ Name ]:
AQ-101

[Synonym ]:
2-Chloro-N-(4,5-dihydroxy-9,10-dioxo-9,10-dihydro-2-anthracenyl)acetamide
Acetamide, 2-chloro-N-(9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenyl)-

Biological Activity

[Description]:

AQ-101 is a novel small-molecule anthraquinone analog that induces MDM2 protein degradation (Kd=0.37 uM) through a self-ubiquitination and proteasome-mediated mechanism, leading to activation of p53; induces apoptosis of acute lymphoblastic leukemia (ALL) especially those with a wild-type p53 phenotype and MDM2 expression in vitro and in vivo; inhibits development of ALL in nude or SCID mice with a human ALL xenograft.

[References]

References 1. Gu L, et al. Mol Cancer Ther. 2018 Feb;17(2):497-507. View Related Products by Target MDM2-p53

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
639.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₀ClNO₅

[ Molecular Weight ]:
331.707

[ Flash Point ]:
340.7±31.5 °C

[ Exact Mass ]:
331.024750

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.749

AQ-101

Names

Biological Activity

Chemical & Physical Properties

Related Compounds