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5,7,3',4'-Tetrahydroxy-3-Methoxy-8,5'-diprenylflavone

Names

[ CAS No. ]:
1353676-65-9

[ Name ]:
5,7,3',4'-Tetrahydroxy-3-Methoxy-8,5'-diprenylflavone

[Synonym ]:
4H-1-Benzopyran-4-one, 2-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-3-methoxy-8-(3-methyl-2-buten-1-yl)-
2-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-3-methoxy-8-(3-methyl-2-buten-1-yl)-4H-chromen-4-one

Biological Activity

[Description]:

5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone is a natural product that can be extracted from B. papyrifera. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone has potent anti-proliferation effects on ER-positive breast cancer cells, with an IC50 value of 4.41 μM for MCF-7 cells. 5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone also reduces the tumor growth in the BCAP-37 xenograft[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. FujiangGuo, et al. Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo. Phytochemistry Letters. Volume 6, Issue 3, August 2013, Pages 331-336.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
694.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C26H28O7

[ Molecular Weight ]:
452.496

[ Flash Point ]:
234.7±25.0 °C

[ Exact Mass ]:
452.183502

[ LogP ]:
6.20

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds