Sulfanitran-13C6

Names

[ Name ]:
Sulfanitran-13C6

[Synonym ]:
N-[4-(4-Nitrophenylsulfamoyl)phenyl-13C6]acetamide
Sulfanitran-(sulfanilamide ring-13C6)
N-{4-[(4-Nitrophenyl)sulfamoyl](13C6)phenyl}acetamide
N4-Acetyl-N1-(4-nitrophenyl)sulfanilamide-13C6
Acetamide, N-[4-[[(4-nitrophenyl)amino]sulfonyl]phenyl-1,2,3,4,5,6-13C6]-
MFCD20527277

Biological Activity

[Description]:

Sulfanitran-13C6 is the 13C6 labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. Eaves KL, et, al. High pressure liquid chromatographic determination of sulfanitran and dinsed in medicated feeds and premixes. J Assoc Off Anal Chem. 1977 Sep;60(5):1064-6.

[3]. Zelcer N, et, al. Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003 Jun 27;278(26):23538-44.