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KH-CB20

Names

[ CAS No. ]:
1354448-60-4

[ Name ]:
KH-CB20

Biological Activity

[Description]:

KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1, with an IC50 of 16.5 nM. KH-CB20 also can inhibits DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CLK1:16.5 nM (IC50)

DYRK1A:57.8 nM (IC50)

CLK3:488 nM (IC50)


[In Vitro]

KH-CB20 shows selectivity for CLK1 (IC50=16.5 nM) over DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM)[1].

[References]

[1]. Fedorov O, et, al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H13Cl2N3O2

[ Molecular Weight ]:
338.19

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds