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WEHI-345 analog

Names

[ CAS No. ]:
1354825-62-9

[ Name ]:
WEHI-345 analog

[Synonym ]:
N-{2-[4-Amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}-3-methyl-2-pyridinecarboxamide
2-Pyridinecarboxamide, N-[2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl]-3-methyl-

Biological Activity

[Description]:

WEHI-345 (analog) is a Src inhibitor, extracted from patent WO/2012003544A1, compound example 71.Target:SrcWEHI-345 (analog) is a protein kinase inhibitor. A family of proto-oncogenic TPKs referred to herein as SFKs (Src family kinases) have provided researchers with a better understanding of the mechanism of cancer as a disease state where normally healthy cellular signalling is disrupted.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Research Areas >> Cancer

[References]

[1]. Jonathan Bayldon Baell, et al. Protein kinase inhibitors and methods of treatment. WO2012003544A1.


[Related Small Molecules]

Saracatinib | PP2 (AG 1879) | A 419259 trihydrochloride | DCC-2036 (Rebastinib) | SU6656 | 1-Naphthyl PP1 | WH-4-023 | Pelitinib | Src Inhibitor-1 | ENMD-2076 | TC-S 7003 | PD173955 | TG 100572 (Hydrochloride) | XL228 | A-196

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
688.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H25N7O

[ Molecular Weight ]:
415.491

[ Flash Point ]:
369.9±31.5 °C

[ Exact Mass ]:
415.212067

[ LogP ]:
2.76

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.678

[ Storage condition ]:
2-8℃

Related Compounds