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CYM50179

Names

[ CAS No. ]:
1355026-47-9

[ Name ]:
CYM50179

[Synonym ]:
2,6-Dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine
Pyridine, 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-
ML-178

Biological Activity

[Description]:

CYM50179 (compound 22n) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor
Research Areas >> Inflammation/Immunology

[Target]

S1PR4:46 nM (EC50)


[References]

[1]. Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
508.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H9Br2Cl2NO2

[ Molecular Weight ]:
441.93

[ Flash Point ]:
261.3±30.1 °C

[ Exact Mass ]:
438.837708

[ LogP ]:
5.62

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.620

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H318-H413

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII

Related Compounds