MK2-IN-28

A potent and selective, non-ATP competitive, allosteric MAPKAPK2/3 (MK2/3) inhibitor with IC50 of 8 nM for MK2, hTNFα EC50 of 0.31 uM; inhibits both MK2 and MK3, and has no or little effect on the other kinases; ameliorates glucose homeostasis by suppressing excessive HGP and enhancing insulin signaling in obese mice.

References 1. Huang X, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):65-70. 2. Ozcan L, et al. Diabetes. 2015 Oct;64(10):3396-405. View Related Products by Target MAPKAPK2 (MK2)