DSR-71167

A novel mineralocorticoid receptor antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM); displays >42-fold selectivity over other steroid receptors (AR, PR and GR); dose-dependently increases urinary excretion of sodium in deoxycorticosterone acetate-treated rats without elevating serum levels of potassium, but not the DSR-30192 (NO carbonic anhydrase inhibitory activity, IC50>100 uM); shows antihypertensive effects in rats.

References 1. Nariai T, et al. J Pharmacol Exp Ther. 2015 Jul;354(1):2-9. View Related Products by Target Mineralocorticoid Receptor (MLR)