N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Names

[ CAS No. ]:
136132-67-7

[ Name ]:
N-ALPHA-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

[Synonym ]:
N-α-CBZ-ARG-ARG 7-AMIDO-4-METHYLCOUMARIN HYDROCHLORIDE

Biological Activity

[Description]:

Z-Arg-Arg-AMC hydrochloride is a selective substrate of cathepsin B[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. Hulkower KI, et, al. Fluorescent microplate assay for cancer cell-associated cathepsin B. Eur J Biochem. 2000 Jul;267(13):4165-70.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₀ClN₉O₆

[ Molecular Weight ]:
658.14800

[ Exact Mass ]:
657.27900

[ PSA ]:
250.54000

[ LogP ]:
5.38490

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Redox Regulation of Pro-IL-1β Processing May Contribute to the Increased Severity of Serum-Induced Arthritis in NOX2-Deficient Mice.

Antioxid. Redox Signal. 23 , 973-84, (2015)

To elucidate the role of reactive oxygen species (ROS) in arthritis and to identify targets of arthritis treatment in conditions with different levels of oxidant stress.Through establishing an arthrit...

Cathepsin B, Cathepsin H, and cathepsin L.

Meth. Enzymol. 80 , 535, (1981)

Post mortem rigor development in the Egyptian goose (Alopochen aegyptiacus) breast muscle (pectoralis): factors which may affect the tenderness.

J. Sci. Food Agric. 96 , 271-9, (2016)

Baseline research on the toughness of Egyptian goose meat is required. This study therefore investigates the post mortem pH and temperature decline (15 min-4 h 15 min post mortem) in the pectoralis mu...