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Amphotericin X1

Names

[ CAS No. ]:
136135-57-4

[ Name ]:
Amphotericin X1

Biological Activity

[Description]:

Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[Target]

MIC: 1 μg/mL (Candida albicans 33/079), 8 μg/mL (C.parapsilosis 937A), 1 μg/mL (Cryptococcus neoformans 451), 2 μg/mL (Aspergillus niger 57A) and 2 μg/mL (A.fumigatus)[1]


[In Vitro]

Amphotericin X1 (compound 4) shows interesting antifungal activity combined with a pronounced reduction in haemolytic activity (EH50 of 42 μg/mL) against mammalianerythrocytes in vitro[1].

[References]

[1]. Taylor AW, et al. Synthesis and antifungal selectivity of new derivatives of amphotericin B modified at the C-13 position. J Antibiot (Tokyo). 1993 Mar;46(3):486-93.

Chemical & Physical Properties

[ Molecular Formula ]:
C48H75NO17

[ Molecular Weight ]:
938.11

Related Compounds