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Arofylline

Names

[ CAS No. ]:
136145-07-8

[ Name ]:
Arofylline

[Synonym ]:
UNII-87L38AY71R
3-(4-chlorophenyl)-3,7-dihydro-1-propyl-1H-purine-2,6-dione
1-n-propyl-3-(4-chlorophenyl)-xanthine
Arofyllin
3-(4-chlorophenyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione
Arofylline (USAN/INN)
Arofylline
3-(p-chlorophenyl)-1-propylxanthine
3,7-dihydro-3-(4-chlorophenyl)-1-propyl-1H-purine-2,6-dione

Biological Activity

[Description]:

Arofylline is a PDE4 inhibitor as a potential treatment for asthma.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[References]

[1]. Chorostowska-Wynimko J, Kus J, Skopińska-Rózewska E. Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 1):95-103.

Chemical & Physical Properties

[ Density]:
1.429g/cm3

[ Boiling Point ]:
562.6ºC at 760 mmHg

[ Molecular Formula ]:
C14H13ClN4O2

[ Molecular Weight ]:
304.73200

[ Flash Point ]:
294ºC

[ Exact Mass ]:
304.07300

[ PSA ]:
72.68000

[ LogP ]:
1.93890

[ Vapour Pressure ]:
1.1E-12mmHg at 25°C

[ Index of Refraction ]:
1.642

Precursor & DownStream

Precursor

DownStream