JKC-301

Names

[ Name ]:
JKC-301

[Synonym ]:
Cyclo(D-Asp-Pro-D-Ile-Leu-D-Trp)
JKC 301
JKC-301

Biological Activity

[Description]:

JKC 301 is a selective Endothelin A receptor antagonist. JKC 301 attenuates the pressor effects of nicotine in rats. JKC 301 can be used to study cardiovascular disease caused by smoking[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

[Target]

Endothelin A receptor[1][2].

[References]

[1]. Tanus-Santos JE, Sampaio RC, Hyslop S, Franchini KG, Moreno H Jr. Endothelin ET(A) receptor antagonism attenuates the pressor effects of nicotine in rats. Eur J Pharmacol. 2000 May 12;396(1):33-7.

[2]. Ngoka LC, et al. Location of alkali metal binding sites in endothelin A selective receptor antagonists, cyclo(D-Trp-D-Asp-Pro-D-Val-Leu) and cyclo(D-Trp-D-Asp-Pro-D-Ile-Leu), from multistep collisionally activated decompositions. J Mass Spectrom. 2000 Feb;35(2):265-76.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₄₄N₆O₇

[ Molecular Weight ]:
624.72800

[ Exact Mass ]:
624.32700

[ PSA ]:
189.80000

[ LogP ]:
2.47420

JKC-301

Names

Biological Activity

Chemical & Physical Properties

MSDS

Click to get detail MSDS

Related Compounds