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Biotin-PEG2-acid

Names

[ CAS No. ]:
1365655-89-5

[ Name ]:
Biotin-PEG2-acid

[Synonym ]:
Propanoic acid, 3-[2-[2-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]ethoxy]ethoxy]-
3-{2-[2-({5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)ethoxy]ethoxy}propanoic acid

Biological Activity

[Description]:

Biotin-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology

[Target]

Non-cleavable


[In Vitro]

Biotin-PEG2-acid is used to cap the N-terminus of the peptide while the peptide was still attached to the resin[1].

[References]

[1]. Merg AD, et al. Seeded Heteroepitaxial Growth of Crystallizable Collagen Triple Helices: Engineering Multifunctional Two-Dimensional Core-Shell Nanostructures. J Am Chem Soc. 2019 Dec 26;141(51):20107-20117.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
752.2±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H29N3O6S

[ Molecular Weight ]:
403.494

[ Flash Point ]:
408.7±32.9 °C

[ Exact Mass ]:
403.177704

[ LogP ]:
-1.05

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.527

[ Storage condition ]:
-20°C

Related Compounds