DNP-PEG3-DNP

Names

[ Name ]:
DNP-PEG3-DNP

[Synonym ]:
N,N'-[Oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis(2,4-dinitroaniline)
Benzenamine, N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis[2,4-dinitro-
MFCD22056318

Biological Activity

[Description]:

DNP-PEG3-DNP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
735.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₄N₆O₁₁

[ Molecular Weight ]:
524.438

[ Flash Point ]:
398.5±32.9 °C

[ Exact Mass ]:
524.150330

[ LogP ]:
3.68

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.647

DNP-PEG3-DNP

Names

Biological Activity

Chemical & Physical Properties

Related Compounds