Spermine NONOate

Names

[ Name ]:
Spermine NONOate

[Synonym ]:
N-[3-aminopropyl-[4-(3-aminopropylamino)butyl]amino]-N-hydroxynitrous amide
1-(3-Aminopropyl)-1-{4-[(3-aminopropyl)amino]butyl}-2-hydroxy-3-oxotriazane
1,3-Propanediamine, N-[4-[1-(3-aminopropyl)-2-hydroxy-3-oxotriazanyl]butyl]-

Biological Activity

[Description]:

Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Spermine NONOate has a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively[1].

[References]

[1]. A Ramamurthi , et al. Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem Res Toxicol. 1997 Apr;10(4):408-13.

[2]. K Homer, et al. In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur J Pharmacol. 1998 Aug 28;356(1):49-57.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
425.4±55.0 °C at 760 mmHg

[ Melting Point ]:
105-107ºC

[ Molecular Formula ]:
C₁₀H₂₆N₆O₂

[ Molecular Weight ]:
262.352

[ Flash Point ]:
211.1±31.5 °C

[ Exact Mass ]:
262.211731

[ PSA ]:
120.21000

[ LogP ]:
-1.03

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.554

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22;S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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