Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2

Names

[ Name ]:
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2

[Synonym ]:
bis-(Bipyridin)-4'-methyl-4-carboxybipy-Ru N-succinimidyl ester.PF6
ru(bpy)2(mcbpy-o-su-ester)(pf6)2
bis(2,2'-bipyridine)-4'-methyl-4-carboxybipyridine-ruthenium n-succinimidyl ester-bis(hexafluorophosphate)

Biological Activity

[Description]:

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs)[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used as a label to measure the hydrodynamic radii of intravitreal anti-VEGF drugs[2].

[References]

[1]. Chen L, et al. Dual-color fluorescence and homogeneous immunoassay for the determination of human enterovirus 71. Anal Chem. 2011 Oct 1;83(19):7316-22.

[2]. Hirvonen LM, et al. Hydrodynamic Radii of Ranibizumab, Aflibercept and Bevacizumab Measured by Time-Resolved Phosphorescence Anisotropy. Pharm Res. 2016 Aug;33(8):2025-32.

[3]. HongfangGao, et al. Highly selective electrogenerated chemiluminescence biosensor for simultaneous detection of matrix metalloproteinase-2 and matrix metalloproteinase-7 in cell secretions. Sensors and Actuators B: Chemical, December 2017, 69-76.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₂₉N₇O₄Ru

[ Molecular Weight ]:
724.73000

[ Exact Mass ]:
725.13200

[ PSA ]:
141.02000

[ LogP ]:
5.89790

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

pH-Dependent Excited-State Dynamics of [Ru(bpy)(3)](2+)-Modified Amino Acids: Effects of an Amide Linkage and Remote Functional Groups.

Inorg. Chem. 38 , 2030, (1999)

The pH-dependent photophysical properties of a series of polypyridyl ruthenium-substituted amino acids were investigated by steady-state and time-resolved luminescence spectroscopy. [H(3)N-DAPA(Rub(2)...

Synthesis of redox derivatives of lysine and related peptides containing phenothiazine or tris(2,2'-bipyridine)ruthenium(II).

Int. J. Pept. Protein Res. 38 , 114, (1991)

Boc-L-Lysine derivatives and lysine-containing peptides bearing the electron donor 10H-phenothiazine (PTZ) or the redox chromophore tris(2,2'-bipyridine)ruthenium(II) dication ([Rub3]2+, where b is 2,...