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Dmt-2'fluoro-da(bz) amidite

Names

[ CAS No. ]:
136834-22-5

[ Name ]:
Dmt-2'fluoro-da(bz) amidite

[Synonym ]:
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxy-2'-fluoroadenosine
Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2'-deoxy-2'-fluoro-

Biological Activity

[Description]:

Dmt-2'fluoro-da(bz) amidite, an uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotide, is a nuclease-resistant antisense compound with high affinity and specificity for RNA targets. Dmt-2'fluoro-da(bz) amidite is also an intermediate for 5’-DMT-3’-phosphoramidite synthesis[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Research Areas >> Others

[References]

[1]. Kawasaki AM, et, al. Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J Med Chem. 1993 Apr 2;36(7):831-41.

Chemical & Physical Properties

[ Molecular Formula ]:
C47H51FN7O7P

[ Molecular Weight ]:
875.923

[ Exact Mass ]:
875.357178

[ LogP ]:
10.49

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds