Okicenone

Names

[ Name ]:
Okicenone

[Synonym ]:
Okicenone
1(2H)-Anthracenone,3,4-dihydro-4,6,9-trihydroxy-8-methyl
3,4-Dihydro-4,6,9-trihydroxy-8-methyl-1(2H)-anthracenone

Biological Activity

[Description]:

Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Meisner NC, et al. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007 Aug;3(8):508-15.

Chemical & Physical Properties

[ Density]:
1.459g/cm3

[ Boiling Point ]:
549.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₅H₁₄O₄

[ Molecular Weight ]:
258.26900

[ Flash Point ]:
300.4ºC

[ Exact Mass ]:
258.08900

[ PSA ]:
77.76000

[ LogP ]:
2.56930

[ Vapour Pressure ]:
6.38E-13mmHg at 25°C

[ Index of Refraction ]:
1.737