FOBISIN 101

FOBISIN 101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively; effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay); also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40.

References 1. Zhao J, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6. 2. Du Y, et al. J Biomol Screen. 2006 Apr;11(3):269-76. 3. Fu H, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2320-4. View Related Products by Target 14-3-3 Protein