nisin Z

Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans[1][4].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

Nisin Z (10 μg/mL, 24 h) 增加牙龈成纤维细胞的脱离和分化[2]。 Nisin Z (25-75 μg/mL，24 小时) 抑制 C. albicans 粘附于牙龈细胞[2]. Nisin Z (500 和 1000 μg/mL，24 小时) 抑制 C. albicans 胚芽管形成[3]. Nisin Z (100 μg/mL，12 小时) 减少 MCF10A 细胞中 LPS 诱导的促炎细胞因子 (即 IL-6、TNF-α、IL-1β) 的产生[4] . Nisin Z (10-100 μg/mL, 12 h) 抑制 LPS 诱导的 MCF10A 细胞中 ERK1/2 和 p38 MAPK 信号通路的激活[4]。 Cell Viability Assay[3] Cell Line: C. albicans Concentration: 100, 500, 1000 μg/mL Incubation Time: 24, 48, and 72 h Result: Reduced C. albicans growth. Western Blot Analysis[4] Cell Line: LPS-induced MCF10A cells Concentration: 10-100 μg/mL Incubation Time: 12 h Result: Inhibited the phosphorylation of p38 and and ERK1/2.

Nisin Z (1、5 和 10 mg/kg，i.p.) 可预防 LPS 引起的小鼠乳腺炎模型中的病理损伤[4]。 Animal Model: Mastitis mouse model[4] Dosage: 1, 5, and 10 mg/kg Administration: i.p., one hour before treatment of LPS. Result: Reduced inflammatory cell infiltration. Showed a reduction in inflammatory cytokine levels.

[1]. Webber JL, et al. Incorporation and antimicrobial activity of nisin Z within carrageenan/chitosan multilayers. Sci Rep. 2021 Jan 18;11(1):1690.  

[2]. Akerey B, et al. In vitro efficacy of nisin Z against Candida albicans adhesion and transition following contact with normal human gingival cells. J Appl Microbiol. 2009 Oct;107(4):1298-307.  

[3]. Le Lay C, et al. Nisin Z inhibits the growth of Candida albicans and its transition from blastospore to hyphal form. J Appl Microbiol. 2008 Nov;105(5):1630-9.  

[4]. Huang F, et al. Nisin Z attenuates lipopolysaccharide-induced mastitis by inhibiting the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways. J Dairy Sci. 2022 Apr;105(4):3530-3543.