N-dodecanoyl-L-Homoserine lactone

Names

[ Name ]:
N-dodecanoyl-L-Homoserine lactone

[Synonym ]:
N-dodecanoyl-HSL
N-dodecanoyl-DL-homoserine
3-dodecanoylamino-dihydro-furan-2-one
n-lauroyl-dl-homoserine lactone
N-Dodecanoyl-L-homoserine lactone
N-dodecanoyl-homoserine lactone

Biological Activity

[Description]:

N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[In Vitro]

Disruption of cell-cell communication or quorum sensing (QS) is considered a stimulating approach for reducing bacterial pathogenicity and resistance[1].

[References]

[1]. Borges A, et al. Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes. Biofouling. 2017 Feb;33(2):156-168.

Chemical & Physical Properties

[ Density]:
1.005g/cm3

[ Boiling Point ]:
485.84ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₉NO₃

[ Molecular Weight ]:
283.40600

[ Flash Point ]:
247.627ºC

[ Exact Mass ]:
283.21500

[ PSA ]:
55.40000

[ LogP ]:
3.72990

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.477

N-dodecanoyl-L-Homoserine lactone

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds