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EML4-ALK kinase inhibitor 1

Names

[ CAS No. ]:
1373409-08-5

[ Name ]:
EML4-ALK kinase inhibitor 1

Biological Activity

[Description]:

EML4-ALK kinase inhibitor 1 is a potent oral active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

[Target]

IC50: 1 nM (EML4-ALK)[1].


[References]

[1]. Iikubo K, et al. Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors. Bioorg Med Chem. 2019 Apr 15;27(8):1683-1692.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H48N8O3

[ Molecular Weight ]:
580.76

Related Compounds