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Osteostatin (human) trifluoroacetate salt

Names

[ CAS No. ]:
137348-10-8

[ Name ]:
Osteostatin (human) trifluoroacetate salt

[Synonym ]:
L-Arginine, L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidy&#xD; l-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-
L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L&#xD; -seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine
Osteostatin (human) trifluoroacetate salt

Biological Activity

[Description]:

Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Thyroid Hormone Receptor
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[In Vitro]

Osteostatin (100, 250 and 500 nM) 剂量依赖性的降低破骨细胞的分化，但不改变成熟破骨细胞的吸收能力。此外，Osteostatin 可降低组织蛋白酶K、破骨细胞相关IG样受体(OSCAR)和NFATc1的mRNA水平[1]。 Osteostatin可增强含Zn2+离子的介孔玻璃支架在人间充质干细胞培养中的生物活性[2]。

[References]

[1]. Lidia Ibáñez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551.  

[2]. C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C142H228N42O58

[ Molecular Weight ]:
3451.576

[ Exact Mass ]:
3449.618164

[ LogP ]:
-9.35

[ Index of Refraction ]:
1.670

Related Compounds