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Ubrogepant

Names

[ CAS No. ]:
1374248-77-7

[ Name ]:
Ubrogepant

[Synonym ]:
(3'S)-N-((3S,5S,6R)-6-Methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl)-2'-oxo-1',2',5,7-tetrahydrospiro(cyclopenta(b)pyridine-6,3'-pyrrolo(2,3-b)pyridine)-3-carboxamide
Spiro(6H-cyclopenta(b)pyridine-6,3'-(3H)pyrrolo(2,3-b)pyridine)-3-carboxamide,1',2',5,7-tetrahydro-N-((3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl)-2'-oxo-,(3'S)
Ubrogepant [USAN]
MK-1602
Ubrogepant

Biological Activity

[Description]:

Ubrogepant (MK-1602) is a novel oral calcitonin gene-related peptide receptor (CGRP) antagonist in development for acute treatment of migraine[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CGRP Receptor
Signaling Pathways >> Neuronal Signaling >> CGRP Receptor
Research Areas >> Cardiovascular Disease
Research Areas >> Neurological Disease

[Target]

MK-1602[1]


[References]

[1]. Li CC, et al. Population PK Analyses of Ubrogepant (MK-1602), a CGRP Receptor Antagonist: Enriching In-Clinic Plasma PK Sampling With Outpatient Dried Blood Spot Sampling. J Clin Pharmacol. 2017 Nov 14. doi: 10.1002/jcph.1021.


[Related Small Molecules]

Olcegepant | BMS-927711 | MK-0974 | MK-3207 HCl | Calcitonin Gene Related Peptide Fragment 8-37 human | Rat CGRP-(8-37) | Adrenomedullin (22-52) (human) | β-CGRP (human)

Chemical & Physical Properties

[ Density]:
1.45±0.1 g/cm3(Predicted)

[ Boiling Point ]:
729.4±60.0 °C(Predicted)

[ Molecular Formula ]:
C29H26F3N5O3

[ Molecular Weight ]:
549.54400

[ Exact Mass ]:
549.19900

[ PSA ]:
111.27000

[ LogP ]:
4.12840

Related Compounds