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Sulfo-ara-F-NMN

Names

[ CAS No. ]:
1374663-29-2

[ Name ]:
Sulfo-ara-F-NMN

Biological Activity

[Description]:

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Neurological Disease

[In Vitro]

Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death[1].

[References]

[1]. Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H14FN2O6PS

[ Molecular Weight ]:
352.28

Related Compounds