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Bisindolylmaleimide III

Names

[ CAS No. ]:
137592-43-9

[ Name ]:
Bisindolylmaleimide III

[Synonym ]:
1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Biological Activity

[Description]:

Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide III selectively interacts with either PKCα or ribosomal S6 protein kinase 1 after activation of these kinases[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[Target]

PKCα


[References]

[1]. Brehmer D, et, al. Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors. Mol Cell Proteomics. 2004 May;3(5):490-500.  

[2]. Saito Y, et, al. Role of ecto-kinase in phorbol ester-enhanced growth hormone-binding protein release from human IM-9 cells. Mol Cell Endocrinol. 1999 Jun 25;152(1-2):65-72.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
708.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H20N4O2

[ Molecular Weight ]:
384.43

[ Flash Point ]:
382.4±32.9 °C

[ Exact Mass ]:
384.158630

[ PSA ]:
92.91000

[ LogP ]:
3.15

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.739

Related Compounds