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ent-Ezetimibe

Names

[ CAS No. ]:
1376614-99-1

[ Name ]:
ent-Ezetimibe

[Synonym ]:
ent-Ezetimibe
(3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
Ezetimibe Impurity 1

Biological Activity

[Description]:

ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.

[2]. Yijun Zhu, et al. Efficient and scalable process for the synthesis of antihypercholesterolemic drug ezetimibe. An International Journal for Rapid Communication of Synthetic Organic Chemistry

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21F2NO3

[ Molecular Weight ]:
409.42500

[ Exact Mass ]:
409.14900

[ PSA ]:
60.77000

[ LogP ]:
4.95330

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds