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Thiol-PEG2-acid

Names

[ CAS No. ]:
1379649-73-6

[ Name ]:
Thiol-PEG2-acid

[Synonym ]:
3-[2-(2-Sulfanylethoxy)ethoxy]propanoic acid
MFCD24503001
Propanoic acid, 3-[2-(2-mercaptoethoxy)ethoxy]-

Biological Activity

[Description]:

Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
329.0±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H14O4S

[ Molecular Weight ]:
194.249

[ Flash Point ]:
152.8±25.1 °C

[ Exact Mass ]:
194.061279

[ LogP ]:
0.06

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.485

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds