TC-2153

TC-2153 is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM; increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures, shows specificity towards STEP compared to several other tyrosine phosphatases; improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.

References 1. Kulikov AV, et al. Psychopharmacology (Berl). 2012 Jun;221(3):469-78. 2. Xu J, et al. PLoS Biol. 2014 Aug 5;12(8):e1001923. 3. Baguley TD, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6. 4. Chatterjee M, et al. Neuropharmacology. 2018 Jan;128:43-53. View Related Products by Target Protein Phosphatase/PTP