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IHVR-11029

Names

[ CAS No. ]:
1383152-30-4

[ Name ]:
IHVR-11029

[Synonym ]:
(2R,3R,4R,5S)-1-[6-(2,5-Difluorophenoxy)hexyl]-2-(hydroxymethyl)-3,4,5-piperidinetriol
3,4,5-Piperidinetriol, 1-[6-(2,5-difluorophenoxy)hexyl]-2-(hydroxymethyl)-, (2R,3R,4R,5S)-

Biological Activity

[Description]:

IHVR-11029 is a small molecule inhibitor of ER α-glucosidases, with an EC50 of 0.09 μM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Glucokinase
Research Areas >> Inflammation/Immunology

[Target]

EC50: 0.09 μM (ER α-glucosidases)[1].


[In Vitro]

IHVR-11029 exhibits EC50 values of 1.3 μM, 3.3 μM and 0.75 μM for BVDV, TARV and DENV, respectively.

[References]

[1]. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res. 2013 Jun;98(3):432-40.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
546.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H27F2NO5

[ Molecular Weight ]:
375.41

[ Flash Point ]:
284.4±30.1 °C

[ Exact Mass ]:
375.185730

[ LogP ]:
2.54

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.551

Related Compounds