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Cabazitaxel-d9

Names

[ CAS No. ]:
1383572-19-7

[ Name ]:
Cabazitaxel-d9

[Synonym ]:
Benzenepropanoic acid, β-[[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]oxy]carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12 ; a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
Cabazitaxel-d9
(2α,5β,7β,10β,13α)-4-Acetoxy-1-hydroxy-13-({(2R,3S)-2-hydroxy-3-[({[2-(2H3)methyl(2H6)-2-propanyl]oxy}carbonyl)amino]-3-phenylpropanoyl}oxy)-7,10-dimethoxy-9-oxo-5,20-epoxytax -11-en-2-yl benzoate

Biological Activity

[Description]:

Cabazitaxel-d9 is deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Tai X, et al. Cabazitaxel and indocyanine green co-delivery tumor-targeting nanoparticle for improved antitumor efficacy and minimized drug toxicity. J Drug Target. 2016 Sep 9:1-29.

[3]. Gdowski AS, et al. Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain. Nanomedicine (Lond). 2017 Sep;12(17):2083-2095.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
870.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C45H48D9NO14

[ Molecular Weight ]:
844.99

[ Flash Point ]:
480.4±34.3 °C

[ Exact Mass ]:
844.434387

[ LogP ]:
7.55

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.592

Related Compounds