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m-PEG10-amine

Names

[ CAS No. ]:
1383658-09-0

[ Name ]:
m-PEG10-amine

[Synonym ]:
2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-amine
MFCD27977522

Biological Activity

[Description]:

m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Jennifer Riggs-Sauthier, et al. Polymer-semaxanib moiety conjugates. US20140011855A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
518.9±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H45NO10

[ Molecular Weight ]:
471.583

[ Flash Point ]:
254.4±22.4 °C

[ Exact Mass ]:
471.304352

[ LogP ]:
-3.88

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.456

[ Storage condition ]:
2-8°C

Related Compounds