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Antileukinate

Names

[ CAS No. ]:
138559-60-1

[ Name ]:
Antileukinate

[Synonym ]:
ac-rrwwcr-nh2
ac-arg-arg-trp-trp-cys-arg-nh2

Biological Activity

[Description]:

Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CXCR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> CXCR

[In Vitro]

Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM[2]. Antileukinate (10 μM, 100 μM) significantly suppresses eosinophil chemotaxis to human eotaxin[2].

[In Vivo]

Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury[1]. Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil[2]. Animal Model: Swiss mice(20-25g)[1] Dosage: 52.63 mg/kg Administration: Subcutaneous injection Result: Reduced pancreatic edema induced by Caerulein (50 μg/kg).

[References]

[1]. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8.

[2]. Yuji Fukuno, et al. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Cytokine. 2003 Jun 7;22(5):116-25.

Chemical & Physical Properties

[ Molecular Formula ]:
C45H66N18O7S

[ Molecular Weight ]:
1003.19000

[ Exact Mass ]:
1002.51000

[ PSA ]:
473.77000

[ LogP ]:
4.18650

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds