3,6,9-Trioxaundecanedioic acid

Names

[ Name ]:
3,6,9-Trioxaundecanedioic acid

[Synonym ]:
2,2'-[Oxybis(2,1-ethanediyloxy)]diacetic acid
2-[2-[2-(carboxymethoxy)ethoxy]ethoxy]acetic acid
2,2'-[Oxybis(ethane-2,1-diyloxy)]diacetic acid
Acetic acid, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-

Biological Activity

[Description]:

369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
443.7±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₄O₇

[ Molecular Weight ]:
222.193

[ Flash Point ]:
178.3±18.1 °C

[ Exact Mass ]:
222.073959

[ PSA ]:
102.29000

[ LogP ]:
-1.96

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.474

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
41

[ Safety Phrases ]:
26-39

[ RIDADR ]:
UN 1760

[ Packaging Group ]:
III

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%