Sodium tetradecyl sulfate

Names

[ CAS No. ]:
139-88-8

[ Name ]:
Sodium tetradecyl sulfate

[Synonym ]:
MFCD00072416
Tergitol 4
TERGITOL
Sodium tetradecyl sulfate
XLT4 Agar Supplement
Tergitol penetrant 4
Tetradecilsulfato sodico
Varicol
EINECS 205-380-3
sodium,(7-ethyl-2-methylundecan-4-yl) sulfate
Sodium sotradecol
Trombovar
Tergitol anionic 4
Obliterol

Biological Activity

[Description]:

Sodium tetradecyl sulfate (Tergitol 4) is a sclerosing agent used for the research of varicose veins[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Jenkinson HA, et al. Sodium Tetradecyl Sulfate: A Review of Clinical Uses. Dermatol Surg. 2017;43(11):1313-1320.

[2]. Park SH, et al. Sodium Tetradecyl Sulfate-Induced Acute Allergic Interstitial Nephritis. Cardiovasc Intervent Radiol. 2017;40(7):1125-1128.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₉NaO₄S

[ Molecular Weight ]:
316.43200

[ Exact Mass ]:
316.16800

[ PSA ]:
74.81000

[ LogP ]:
4.95530

[ Index of Refraction ]:
n20/D 1.39

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ2800000

CHEMICAL NAME :: 4-Undecanol, 7-ethyl-2-methyl-, hydrogen sulfate, sodium salt

CAS REGISTRY NUMBER :: 139-88-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C14-H29-O4-S.Na

MOLECULAR WEIGHT :: 316.48

WISWESSER LINE NOTATION :: WSQOY2Y4&2&1Y1&1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/13/1963

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AROPAW Archives of Ophthalmology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) New series: V.1-44(3), 1929-50; V.64- 1960- Volume(issue)/page/year: 34,99,1945 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - hematuria

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,478,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/13/1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - hematuria

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,478,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,478,1941 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0051 No. of Facilities: 20 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 2874 (estimated) No. of Female Employees: 108 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;Xi: Irritant;

[ Risk Phrases ]:
36/37/38-34-21/22

[ Safety Phrases ]:
S26;S45;S36/S37/S39

[ RIDADR ]:
UN 3267 8/PG 3

Articles

Improved plating media for the detection of Salmonella species with typical and atypical hydrogen sulfide production.

J. Vet. Diagn. Invest. 12 , 83-7, (2000)

The Salmonella detection ability of 2 surfactant-supplemental media, xylose-lysine-tergitol (Nia-proof) 4 (XLT4) and Miller-Mallinson (MM) agar, was compared against that of several commonly used plat...

Salmonella and Escherichia coli O157:H7 contamination on hides and carcasses of cull cattle presented for slaughter in the United States: an evaluation of prevalence and bacterial loads by immunomagnetic separation and direct plating methods.

Appl. Environ. Microbiol. 74(20) , 6289-97, (2008)

The hide and carcass hygiene of cull cattle at slaughter in four geographically distant regions of the United States was examined from July 2005 to April 2006 by measuring the aerobic plate counts (AP...

Physical Chemistry of the Thermal Transformation of Mesoporous and Microporous Zirconia Pacheco, G. and J. J. Fripiat

J. Phys. Chem. B 104 , 11906, (2000)