BM-1197

BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo.

References 1. Bai L, et al. PLoS One. 2014 Jun 5;9(6):e99404. 2. Ye L, et al. Tumour Biol. 2015 May;36(5):3447-55. 3. Acasigua GA, et al. Oral Oncol. 2015 Sep;51(9):839-47. View Related Products by Target Bcl-2