Azido-PEG11-azide

Names

[ Name ]:
Azido-PEG11-azide

[Synonym ]:
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane, 1,35-diazido-
1,35-Diazido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane

Biological Activity

[Description]:

Azido-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₄₈N₆O₁₁

[ Molecular Weight ]:
596.672

[ Exact Mass ]:
596.338135

[ LogP ]:
-3.09

Azido-PEG11-azide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds